Chelsea goalkeeper Thibaut Courtois questioned whether Tottenham will be able to thrive at Wembley this season due to a lack of noise generated by the fans.
Spurs are using England's national stadium for their home matches this season while the redevelopment work at White Hart Lane continues.
They got off to an inauspicious start on Sunday, though, as Premier League champions Chelsea claimed a 2-1 victory to make it seven defeats in their last nine appearances at Wembley for Mauricio Pochettino's side.
And Courtois believes they might continue to struggle if the home support are unable to create a more intimidating atmosphere.
"It feels a bit different because obviously their home ground is not this one," he said. "They have the capacity now to bring a lot of fans into the stadium.
"If they make more noise it would be better for them but in the first half, if you have to put some noise over the speakers to make some atmosphere, I don't think it is working very well.
8 - Harry Kane had eight shots v Chelsea; the most he has recorded in a single Premier League game without scoring. Blunt. pic.twitter.com/XqPkdDpqvC— OptaJoe (@OptaJoe) August 20, 2017
"In the second half they were pressing and 70,000 people started to wake up. There is obviously more than the 40,000 [36,284] at White Hart Lane.
"The only difference is that they are more separated from the pitch than at White Hart Lane, where you feel more pressure when they are pressing and the pitch is smaller. That is probably better for them.
"Wembley is an amazing stadium and makes you want to play even better, it is like a Champions League game where you can rise above yourself.
"All the teams that come here, instead of being impressed, they will give more, so for Spurs it won't be easy.
"But if they have their fans, with 80-90,000 people, they can make it difficult for a lot of teams."
|Dybala hails Messi as ´our Maradona´, wants to play with Neymar|
|Sherwood talks up Spurs as potential Champions League winners|
|Borussia Dortmund on the brink as Real Madrid eye progress - Champions League in Opta numbers|
|Hughton hopeful on video assistance after Brighton denied penalty|
|Klopp staying calm over Salah form|
|Griezmann: I don´t regret staying at Atletico|
|Guardiola dismisses Champions League favourites tag|
|Brighton and Hove Albion 2 Stoke City 2: Gross, Izquierdo extend home unbeaten run|
|Rose in contention to face Dortmund as Pochettino denies ´issue´ with defender|
|Benzema knows he can give more – Zidane|
|I´ve fulfilled my dreams already – Klopp has no plans to coach Barcelona|
|Aubameyang will face Tottenham, Bosz confirms|
|Klopp expects Matip to face Chelsea, Lallana return getting ´nearer´|
|Berizzo looking to former Red Aspas to provide lessons for Sevilla|
|Mangala ready to pounce, but realistic on Man City playing time|
|Mendy injury means Aguero or Jesus for Guardiola|
|Guardiola sends ´big hug´ to ´amazing, so gentle´ Pulis|
|Tavecchio quits as head of FIGC, claims board have refused to resign|
|Benedetto facing Argentina World Cup KO with cruciate injury|
|Shape up! Heynckes reveals demand to Bayern star Vidal|
|Ramos sits out Madrid trip to APOEL|
|West Brom sack Pulis after wretched run|
|Lloris wants Spurs to forget title and focus on top four|
|Pogba no Gerrard yet, says Benitez|
|Guardiola will ´kill´ City stars if they get complacent|
|Ibrahimovic: My injury was worse than people know|
|Icardi like a ´raptor pouncing on its prey´, says Spalletti|
|City style suits me and thrills neutrals, says De Bruyne|
|Guardiola ready to risk Kompany for Man City after Stones´ injury|
|Stones can bounce back stronger - Kompany|
|In-form Chelsea have regained hunger - Conte|
|Inter 2 Atalanta 0: Icardi brace sends Spalletti´s side second|
|Giampaolo promises more from ´extraordinary´ Sampdoria|
|Record-breaking Valencia tee up blockbuster Barcelona clash|
|Poor West Ham performance at Watford was to be expected - Moyes|
|We will see what happens in the future - Silva non-committal on Everton rumours|
|Stones can bounce back stronger - Kompany|
|Football needs to do more to combat racism - Boateng|
|Watford 2 West Ham 0: Misery for Moyes on Hammers bow|
|Unlucky 13: Benevento suffer record-breaking defeat|
|Juventus lost composure amid Sampdoria onslaught - Allegri|
|Sampdoria 3 Juventus 2: Champions slip further off the pace after thriller|
|Coleman confirmed as Sunderland boss|
|I was just injured - Belgium´s Nainggolan blasts ´stupid´ claims of feigned ailment|
|Leeds United 2 Middlesbrough 1: Losing streak snapped to ease pressure on Christiansen|
|Hughes backs Giggs for Wales job|
|Madrid confirm Ramos´ broken nose after derby clash|
|Kane wants to retire with Tottenham|
|Mourinho: Man United lacked balance with attacking line-up|
|Pastore not considering PSG exit to help World Cup chances|
|Wenger, Ozil & Sanchez uncertainty affecting Arsenal, says Seaman|
|Silva not surprised by Chelsea, Spurs interest in Richarlison|
|Ancelotti, Conte, Allegri on shortlist to replace Ventura|
|Perth Glory 0 Melbourne Victory 2: Visitors claim first A-League win of season|
|Marcelo unaware of Ramos-Ronaldo rift at Real Madrid|
|Neymar will take PSG´s next penalty - Cavani|
|Ranieri would consider coaching Italy|
|Postecoglou set for decision on Socceroos future|
|Championship Review: Millwall deny sloppy Sunderland, Wolves back on top|
|Simeone rallies around under-fire Griezmann|
|It´s a growth process - Montella optimistic despite Napoli loss|
|Spalletti happy at Inter, tips Ancelotti for Italy job|
|Sarri defends sacked Ventura over Insigne´s Italy snub|